Studies on Nutritional Factors in Mammalian Development

It is a special pleasure for me today to be able to contribute some small part to the honoring of my professor, Dr. Agnes Fay Morgan, who has had a most impor tant influence on my life and continues to be a source of inspiration. Much of the work I shall discuss saw its beginnings in the investigations of distinguished researchers who are present today, both as speakers and as members of the audience. This example of the continuity of our science provides a fitting tribute to our guest of honor and to her dedication to the future of nutrition research. My subject, the role of nutritional factors in mammalian embryonic development, fits appropriately in the context of the theme of this symposium, because it is during the time-span being discussed today that research on this subject began. Systematic studies of the influence of nutrition on the prenatal development of mammals can be said to have begun with the observations of Hale about 1935 .  Before this time, a considerable number of experiments had been carried out with avian and amphibian eggs, and it was recognized that environmental factors could influence the development of these embryos. Yet even in these species, little thought was given to the role of nutrition in embryonic development, and as far as mammalian embryos were concerned, genetics claimed the day.

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